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Ataxia Support Network

tDCS surprise


#12

TAKE-HOME MESSAGE

  • Noninvasive stimulation of cerebellar and spinal cord structures has shown promise in the treatment of ataxic symptoms, and this is interesting particularly in the field of neurodegenerative ataxias, which lack effective therapies. The authors of this randomized, double-blind, sham-controlled, crossover trial combined cerebellar anodal transcranial direct current stimulation (tDCS) and spinal cathodal tDCS in patients with ataxia (including spinocerebellar ataxia type 2, cerebellar variant of multiple system atrophy type C, and other syndromes). The mean score on the Scale for the Assessment and Rating of Ataxia changed from 20.1 at baseline to 15.8 at the end of the 2-week stimulation period, with benefit sustained at 1 month (15.1) and 3 months (16.1). A similar pattern was seen for the International Cooperative Ataxia Rating Scale score and secondary measures. The greatest improvement was seen in patients who were less affected clinically and functionally.
  • The results suggest a promising potential role for this therapeutic approach in treatment of neurodegenerative ataxia, with further research warranted.

– Codrin I. Lungu, MD


#13

Unit/model I don’t know. All your other questions are documented in the referenced study.


#14

Yep I went to the Attadale clinic.


#15

Has anyone used tDCS device that’s available through Amazon?


#16

I would have to say here I’d be very sceptical about such a device from Amazon. Any such treatments should be conducted under medical supervision IMO. A TENS machine for muscular tension is one thing, but tDCS is something altogether different and not something I’d be suggesting under any circumstances without a knowledgeable practitioner.

Merl from the Moderator Support Team


#17

Agreed. I was just asking if anyone had any experience.


#18

Yes, Shoaib I do have some experience with tDCS. I purchased my unit from “The Brain Stimulator” https://thebrainstimulator.net/. They were very nice and I got all information on where to position the electrodes, voltage, etc. by going to my current favorite site https://clinicaltrials.gov/ct2/home. There is also a bunch of information on the web by using google. Checking my diary, I used the device twice for 3 weeks with no luck. I gave up on using the device but will look into starting up again.


#19

Thank you for sharing your experience. Sometimes, hearing about true experiences are necessary then being politically correct.


#20

Your welcome! I’ve tried them all! If you have any additional questions, please post to me.


#21

I see you were also on clinical trial 4157. Any luck in using the pill? After 1 year, it proved to be a dud for me.


#22

There was improvement with BHV-4157. They say there was no deterioration either while on it. Go figure.


#23

I read that Biohaven will be introducing a clinical trial for TRORILUZOLE, BHV 4157-206. This was mentioned on a recent newsletter from www.ataxia.org :slightly_smiling_face: xB


#24

This is supposed to be slowing the progression of the disease. It’s an expansion study of the previous BHV 4157. I initially heard from Johns Hopkins, but nothing recently.


#25

I am not being able to go to Las Vegas for the annual NAF meeting next year. If anyone goes, could you learn more about tDCS ( Transcutaneous Direct Current Stimulation) ? This seems to be interim method to improve cerebellar function till gene editing or stem cell infusion are successful.


#26

I hope to try it soon for my daughter also… What do you think when will it be available on the market?


#27

Although tDCS had shown some promising results on the cerebellum, I am yet to see any FDA approved or cleared device in that regard.


#28

I’m curious, where did you read recently that there is promising results from using tDCS?


#29


They are all over.


#30

Dear Shoaib, now that some time has passed since you tested this tDCS, what is your current thought on it? Did it improve your symptoms? Did improvement last?


#31

I had never been on tDCS. But it’s about 10days I had been on Biohaven expanded study with Trigriluzole ( BHV 4157). I would also be interested to know more about tDCS.