Episodic ataxia type 2 (EA2) is characterized by paroxysmal attacks of ataxia, vertigo, and nausea typically lasting minutes to days in duration. Attacks can be associated with dysarthria, diplopia, tinnitus, dystonia, hemiplegia, and headache. About 50% of individuals with EA2 have migraine headaches.24 Feb 2003
www.ncbi.nlm.nih.gov › NBK1501
EA is poorly understood, even within the ataxia community. The problem being between episodes the patient can carry on as normal.
Diagnosis is confirmed by testing for the gene, along with a history of symptoms. Cerebellar Atrophy is not always present.
Re the question of medication… Given the choice, I would stay with the one more likely to prevent seizures. Acetazolamide is the drug of choice for many Neurologists, it could very well depend on the dosage as to whether it proves effective, but then it won’t be the right anti epilepsy drug appropriate for everyone diagnosed with EA2. 4-AP is not associated with preventing seizures.
Episodic ataxia type 2
Acetazolamide is the pharmacological treatment of choice for EA2; a dosage between 250 and 1000 mg/day is usually effective.19 Acetazolamide 250 mg/day could fully suppress EA episodes in our EA2 patient. Alternatively, 4-aminopyridine can be used. Other drugs, including dalfampridine, have been proposed as potential treatment options, but further studies are still needed.19
Copied from www.ncbi.nlm.nih.gov
The National Ataxia Foundation (www.ataxia.org) provide a list of medications they suggest appropriate for ataxia symptoms. 4-AP is suggested for dizziness and vertigo, and Nystagmus.